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In Issue 4 of the Journal of the National Cancer Institute, one study looked at the number of oncology and hematology drug reviews and subsequent approvals at the FDA from 2005 to 2007. Also, a study and editorial focused on symptoms and their value for early detection of ovarian cancer, while another found that three commonly used esophageal cancer cell lines in research proved to be from other cancers. In another study, researchers found that the addition of the contrast agent gadolinium during MRI for primary tumor assessment improved accuracy for detecting lymph node metastases. And in this issue's last study, researchers found that childhood survivors of CNS cancers and leukemia have lowered educational success.