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The June 3 issue of JNCI features articles on antioxidant supplementation during radiation therapy or chemotherapy, the role of overlapping tumor suppressors in melanoma, and the relationship between vitamin D levels in the blood and the risk of prostate cancer. Also in the Journal are a randomized trial on the addition of taxanes to standard adjuvant chemotherapy for women with lymph node-positive breast cancer and a study of estrogen-dependent signaling in an aggressive form of prostate cancer.