The March 18 issue of JNCI includes one study on estimating the risk of breast cancer and another on overdiagnosis and lead times in PSA screening for prostate cancer. Also in this issue is a study suggesting that folic acid supplements increase the risk of prostate cancer; a study showing how herpesvirus may interfere with cell death; mechanistic data linking human papillomavirus to head and neck cancer; and a study suggesting that some blood types are associated with an elevated risk of pancreatic cancer.