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The May 5 issue of JNCI includes a report about dietary acrylamide and its association with lung cancer risk and a study on gene alterations in response to anthracycline-based therapy. The issue also includes a commentary describing the design of clinical trials to test the impact of physical activity and weight control on breast cancer risk and a study showing that the clusterin gene acts as a tumor suppressor in mouse models of neuroblastoma. Last, there is a report showing that Danish women who are survivors of pediatric cancer are no more likely to terminate a pregnancy than their sisters or women in the general population.