in this episode, we explore Chronic Lymphocytic Leukemia (CLL), the most common adult leukemia in the Western world, characterized by the progressive accumulation of malignant B lymphocytes. Diagnosis relies on flow cytometry, but because the disease is typically indolent, initial management is generally a "watch and wait" approach until symptoms appear, as early intervention does not improve overall survival. When treatment is needed, the current paradigm favors targeted agents—such as Bruton tyrosine kinase (BTK) inhibitors and Bcl-2 inhibitors (venetoclax)—over traditional chemoimmunotherapy.
ORPHA:67038
Classification level: Disorder
Source: PubMed ID 36446777 32229611 37899041
Prevalence: 1-5 / 10 000
Inheritance: Multigenic/multifactorial, Not applicable
Age of onset: Adult
ICD-10: C91.1
ICD-11: 2A82.0
OMIM: 109543 151400609630 612557 612558612559
UMLS: C0023434
MeSH: D015451
GARD: 6104
MedDRA: 10008958
