Chronic ethanol exposure impairs value-based decision-making by altering striatal neurocomputations, particularly in the dorsomedial striatum, with male rats showing reduced adaptability and disrupted encoding of choices and outcomes. These effects were sex-specific, as female rats exhibited minimal behavioral changes but distinct neural alterations, highlighting differential vulnerability in striatal dynamics.
Cheng Y, Magnard R, Langdon AJ, Lee D, Janak PH. Chronic ethanol exposure produces sex-dependent impairments in value computations in the striatum. Sci Adv. 2025 Apr 4
