The University of Arizona is on the land and territories of Indigenous Peoples, and today, Arizona is home to 22 federally recognized tribes, with Tucson being home to the O'odham and the Yaqui. There is a disproportionate burden of contaminant exposure in underserved populations like Native Americans, and because their culture and traditions are closely woven with the environment, special strategies must be used to study and help these groups. Dr. Paloma Beamer, professor of public health, research scientist in the Asthma and Airway Disease Research Center, and director of the Community Engagement Core at the Southwest Environmental Health Sciences Center, shares how she takes a culturally-informed approach to conduct research with and devises interventions for Indigenous Peoples.