Certain diseases like Alzheimer’s and high blood pressure are known to alter the link between brain activity and blood flow changes in the brain, leading to improper blood flow delivery to brain cells. This eventually leads to the death of brain cells and cognitive decline. Dr. Paulo Pires, assistant professor of physiology and surgery and BIO5 member, studies how blood flow to the brain changes between healthy and disease states, with an eye on possible therapies that can improve blood flow to mitigate disease.