HRT isn’t always enough. In this episode of Hormone Heroines, Dr. Jannine Krause explains why women still struggle with weight loss, hot flashes, pain, and gut issues despite optimized hormones—and how peptides, bioregulators, and advanced testing can restore true vitality and health span.
In this episode of the Hormone Heroines Podcast, Dr. Jannine Krause—a naturopathic doctor and acupuncturist—dives into why Hormone Replacement Therapy (HRT), while foundational, often fails to resolve lingering symptoms in midlife women. She explains that weight loss plateaus, persistent hot flashes, joint pain, and gut dysfunction are frequently driven by inflammation, metabolic imbalance, vascular dysfunction, or impaired tissue repair rather than hormone levels alone.
Dr. Krause walks through her advanced diagnostic approach, which includes hormone metabolism testing (saliva, blood, and DUTCH), gut testing with GI Map, micronutrient analysis, and inflammatory markers. These insights help identify when patients need more targeted support beyond hormones.
She introduces peptides as “small messengers” that signal the body to heal specific tissues. Foundational peptides like BPC-157 and KPV are highlighted for gut repair, inflammation reduction, ligament and tendon healing, and brain health. For metabolic support, Dr. Krause shares why she prefers low-dose tirzepatide over semaglutide and discusses peptide blends designed for patients seeking alternatives to GLP-1 medications.
The conversation also explores bioregulators—cell-level therapies that help “reset” organ function. Pineal gland regulators such as Pinealon and Endolutin are used for stubborn insomnia and circadian rhythm disruption, while Vesugen supports blood vessels and endothelial health, making it particularly helpful for hot flashes and POTS-like symptoms.
Throughout the episode, Dr. Krause emphasizes safety, individualized care, and the importance of cycling peptides rather than using them indefinitely. Her clinical philosophy centers on microdosing hormones, layering peptides strategically, and sourcing therapies through trusted medical professionals.
The key message: HRT sets the foundation, but peptides and bioregulators are the “icing on the cake” that help women achieve true vitality, resilience, and long-term health span.
Dr. Jannine Krause is a naturopathic doctor and licensed acupuncturist specializing in women’s health, hormone optimization, gut health, and regenerative therapies. Known for her integrative and precision-based approach, Dr. Krause helps patients move beyond symptom management by addressing root causes through advanced testing, peptides, bioregulators, and personalized treatment strategies.
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Hormone Heroines
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