Description

Este episodio es especial pues nos adentramos al chismecito sobre el trabajo galardonado con el Premio Nobel de Química 2020. Acompáñanos mientras Mel nos explica el porqué las tijeras genéticas serán una de las herramientas más importantes en un futuro no muy lejano.

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Referencias:

1. Mojica, F.J., Díez-Villaseñor, C., García-Martínez, J. et al. Intervening Sequences of Regularly Spaced Prokaryotic Repeats Derive from Foreign Genetic Elements. J Mol Evol 60, 174–182 (2005). https://link.springer.com/article/10.1007/s00239-004-0046-3
2. Mojica, F., Ferrer, C., Juez, G. and Rodríguez‐Valera, F. (1995), Long stretches of short tandem repeats are present in the largest replicons of the Archaea Haloferax mediterranei and Haloferax volcanii and could be involved in replicon partitioning. Molecular Microbiology, 17: 85-93. https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2958.1995.mmi_17010085.x
3. Press release: The Nobel Prize in Chemistry 2020. NobelPrize.org. Nobel Media AB 2020. Sun. 1 Nov 2020. https://www.nobelprize.org/prizes/chemistry/2020/press-release/
4. Doudna, J. A., & Charpentier, E. (2014). The new frontier of genome engineering with CRISPR-Cas9. Science, 346(6213), 1258096. https://science.sciencemag.org/content/346/6213/1258096.abstract?casa_token=TjyvAlzAs9cAAAAA:4d53SmLKJqrpZC9hIxcvx6EP72ipKy3jgdVqxmDYLPvHTm0EQ8BjoemEV-w_rvDcsTTn1LHAH3dd2i2y
5. Li, J., Norville, J., Aach, J. et al. Multiplex and homologous recombination–mediated genome editing in Arabidopsis and Nicotiana benthamiana using guide RNA and Cas9. Nat Biotechnol 31, 688–691 (2013). https://www.nature.com/articles/nbt.2654