Can a new "magic pill" be the solution for managing weight? Researchers at UT Health San Antonio investigated the role of magnesium, and specifically a magnesium transporter on mitochondria called Mrs2, on energy and metabolism. Find out how mice without Mrs2 fared against wildtype mice when fed a normal vs Western (read: high fat) diet, and whether magnesium blockers are the key to weight control.
TLDR: Mice lacking the gene responsible for promoting magnesium transport into mitochondria showed improved metabolism and less weight gain on a high-fat diet, which can now be replicated using a new small-molecule drug.
Links:
https://www.sciencedaily.com/releases/2023/03/230322082730.htm
https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00166-3
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