にゃんごう＆いがさんのEBMerな夜
第71回放送 2022/10/30
【にゃんごう：降圧薬服用タイミング】
Mackenzie IS, Rogers A, Poulter NR, Williams B, Brown MJ, Webb DJ, Ford I, Rorie DA, Guthrie G, Grieve JWK, Pigazzani F, Rothwell PM, Young R, McConnachie A, Struthers AD, Lang CC, MacDonald TM; TIME Study Group.
Cardiovascular outcomes in adults with hypertension with evening versus morning dosing of usual antihypertensives in the UK (TIME study): a prospective, randomised, open-label, blinded-endpoint clinical trial.
Lancet. 2022 Oct 22;400(10361):1417-1425. doi: 10.1016/S0140-6736(22)01786-X. Epub 2022 Oct 11.
PMID: 36240838.
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)01786-X/fulltext
【いがさん：リアルワールドにおける臨床試験で除外された患者】
Tan YY, Papez V, Chang WH, Mueller SH, Denaxas S, Lai AG.
Comparing clinical trial population representativeness to real-world populations: an external validity analysis encompassing 43 895 trials and 5 685 738 individuals across 989 unique drugs and 286 conditions in England.
Lancet Healthy Longev. 2022 Oct;3(10):e674-e689. doi: 10.1016/S2666-7568(22)00186-6. Epub 2022 Sep 20.
PMID: 36150402.
https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(22)00186-6/fulltext
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https://goo.gl/forms/5AsPilK7QnB9VrmX2
