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Edema is swelling of soft tissues due to increased interstitial fluid. The fluid is predominantly water, but protein and cell-rich fluid can accumulate if there is infection or lymphatic obstruction. Edema may be generalized or local (eg, limited to a single extremity or part of an extremity). It sometimes appears abruptly; patients complain that an extremity suddenly swells. More often, edema develops insidiously, beginning with weight gain, puffy eyes at awakening in the morning, and tight shoes at the end of the day. Slowly developing edema may become massive before patients seek medical care. In these topic Pathophysiology, Etiology, Evaluation, Treatment, Geriatrics Essentials and Key Points of Edema are discussed.