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Cirrhosis is a late stage of hepatic fibrosis that has resulted in widespread distortion of normal hepatic architecture. Cirrhosis is characterized by regenerative nodules surrounded by dense fibrotic tissue. Symptoms may not develop for years and are often nonspecific (eg, anorexia, fatigue, weight loss). Late manifestations include portal hypertension, ascites, hepatic encephalopathy, and, when decompensation occurs, liver failure. Diagnosis is usually made using noninvasive imaging, although liver biopsy is required on rare occasions. Management involves supportive care and treatment of the causative liver disease.
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Professor Armen Astvatsatryan, MD, PhD, ScD, Fellow of European Society of Cardiology. First Dean and Founder of Faculty of Public Health of European Regional Educational Academy (now University). One of 100 Top Health Professionals - 2007 by the International Biographical Center`s (Cambridge, England)
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