In Exploration Science, Episode 4, we continue our exploration of enzyme-mediated technologies in peptide and protein science. As a follow-up to a question posed in Episode 2, the CEO of EnzyTag, Leendert van den Bos, and Peptide Expert, Rodney Lax, tell us about the growing utility of Chemo-Enzymatic Peptide Synthesis (CEPS) from discovery to manufacturing.
Links and references:
Development of omniligase: https://doi.org/10.1016/j.csbj.2021.02.002
Scale-up work on Exenatide (EnzyPep / PPL collaboration): https://doi.org/10.1039/c9gc03600h
Publication with Danny Chou: https://chemrxiv.org/engage/chemrxiv/article-details/618162db81c4fc61d3ea4954.
Omniligase kit https://enzytag.com/ligation-kit/
CEPS Technology - https://www.youtube.com/watch?v=vtEUWmy-oEM
Protein synthesis - https://www.youtube.com/watch?v=YnMoBs1jbAw
