In Exploration Science Episode 5, Dr. Ved Srivastava, a former president of the American Peptide Society, past co-chair of the American Peptide Symposium, and current VP of Chemistry at Aktis Oncology, walks us through the process of developing peptide therapeutics from discovery to commercialization. Ved is a peptide expert with over 25 years of experience in peptide therapeutics and is the editor of 5 books focused on peptides. This episode has a special mention of the work by Guangcheng Jiang et al. on Degarelix as well as callouts to the initial development of microwave-assisted peptide synthesis and coming breakthroughs in AI and machine learning by the pioneering work at companies like Peptilogics, Pepticom, and Nuritas.
The views and opinions expressed by my guest, Ved Srivastava, are his and do not necessarily reflect the views and opinions of any organization.
Links and references:
1. Links to recent books focused on peptide therapeutics, https://www.amazon.com/vedsrivastava
2. Peptide Therapeutics: Strategy for Chemistry Manufacturing and Control (CMC) (https://pubs.rsc.org/en/content/ebook/978-1-78801-433-5)
3. Implantable Technologies: Peptides and Small Molecules Drug Delivery (https://pubs.rsc.org/en/content/ebook/978-1-83916-222-0)
4. Peptide-based Drug Discovery: Challenges and New Therapeutics (https://pubs.rsc.org/en/content/ebook/978-1-78262-732-6)
5. Comprehensive Medicinal Chemistry III - Volume 7: Biologics Medicine ([www.elsevier.com]www.elsevier.com)
6. ‘Peptide 2015’ (https://www.americanpeptidesociety.org/assets/pdf-files/proceedings/24.pdf)
7. USP Workshop: https://www.usp.org/events-training/workshops/therapeutic-peptides-and- oligonucleotides
8. Degarelix: DOI: 10.1021/jm0003900
