Huff enrolled in Muskogee's Spaulding Institute in 1904. She became the Literary Editor of Central High School's newspaper "The Scout" in 1909. She became a teacher at the same high school in 1916. During the summer of 1922, she taught at New York's Columbia University, due to the success of her 1921 book, " A Manual For Journalism in the High School", which was widely used in the United States. She joined Muskogee Junior College in 1923 and became the dean in 1928. For the next 34 years, Huff directed the school from nine students in 1920 to 292 students in 1953. It became unofficially known as Bessie Huff University. Due to financial problems, it closed in October 1962.
