What a better way to start the new 2024 year than to learn about the current, realistic prospect of living longer and better lives due to the latest advances in medicine and pharmaceutical research from a preventive and longevity medicine advocate, researcher, and expert, James Peyer, PhD. This episode features a personal, candid story of his journey from academia into the industry, inspiration behind pursuing preventive healthcare and longevity treatments, and latest new treatments in human trials that increase healthspan and lifespan from a keynote speech at the 2nd annual global Medical Affairs Innovation Olympics Opening Ceremony in 2023. Subscribe to Alloutcoach and share this episode with your friends!
0:00 Episode Introduction
5:10 James Peyer's Keynote Speech Outline
7:14 James Peyer's late grandfather and inspiration to pursue prevention medicine
7:55 Frustration with Health System's Interaction with Elderly
9:53 Early animal experiments in genes doubling lifespan
11:14 80+ treatments that extend healthy lifespan in animal models today
13:09 Real-world reason why human trials in slowing aging did not advance
14:10 Breakthrough Idea to Advance Prevention Medicine in Humans
16:35 Cambrian Bio's unique Longevity Platform Ecosystem
19:42 Two Longevity Medicine Biotech Case Studies
20:50 Amplifier Therapeutics - a Cambrian Bio Pipeline Company
23:48 New Promise in 10-year race to develop an AMPK (central energy regulator) activator
25:40 ATX-304: new AMPK candidate in human trials
27:50 Second Vignette: Velakor - agrin-induced pleiotropic cardiac repair
31:11 Velakor's Agrin in human clincal trials in 2024 to regenerate heart muscle
33:25 Q1: Regulatory approval considerations for other longevity medicine companies
34:08 Conduct Primary and Secondary Prevention Trials - FDA supportive of preventive treatments
35:21 FDA interested in preventive medicine, transition from sick care to preventive care in US
37:11 Q2: Difference between healthspan and lifespan, and impact on drug development
38:22 Patient Survey Data on Critical Value of Quality not only Length of Life
41:25 Q3: Technological innovations most promising in increasing longevity and healthspan
43:49 James' Final Message on Innovation and Entrepreneurship
