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Today we are going to talk to the CEO and Co-Founder of a leading gene therapy company AskBio Sheila Mikhail about a revolutionary technology of using a VIRUS to cure genetic diseases. Because of this technology the company inventor was acquired for $4 billion dollars.

My today's guest has over 20 years of Biopharmaceutical leadership experience. Most recently she served as Chief Executive Officer and co-founder of Bamboo Therapeutics which was acquired by Pfizer for $827 million. 

In 2021 Sheila was named EY’s 2021 Entrepreneur of The Year National Overall Award winner. 

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00:00 Introduction

02:10 What is AAV gene therapy and what makes this technology revolutionary?

04:25 What inspired you to choose this career? 

06:31 What diseases can be already cured today by AAV gene therapy developed by Ask Bio?

08:28 What diseases can be potentially cured with AAV gene therapy by today we don’t have a cure yet?

09:20 What is Ask Bio company’s mission? Why are you doing what you are doing?

10:15 What critical component of your position makes the work challenging?

12:26 What is your GREATEST Failure Story, what did you learn and how did you recover from it?

15:30 What is your typical way of dealing with difficult situations? Give us an example?

17:02 Who were your Mentors and what is the impact they have on you?

17:59 What are the top 3 Mistakes a CEO should AVOID, based on your own experience?

22:09 What do you like to do outside of work? Do you have any hobbies?

26:56 What do you anticipate for the gene therapy market in the next 10 years? 

28:36 What is the advice you would give to younger yourself?