Studying single molecules provides researchers with unique insights into biological mechanisms and processes and allows them to visualise microscopic structural and functional differences. However, results can be unpredictable, and investigations are labour-intensive and expensive, often requiring extensive training and highly specialised laboratory equipment. Dr Rishabh Shetty and colleagues at Arizona State University, the California Institute of Technology, and the Massachusetts Institute of Technology, USA, have recently developed a simplified single-molecule assessment technique to overcome these limitations with a view to increasing accessibility and precision in molecular-level research.
