This is first part of the conversation with Randy Schekman. He is an investigator of the Howard Hughes Medical Institute and a Professor of Cell and Developmental Biology in the Department of Molecular and Cell Biology at the University of California at Berkeley. He was awarded the Nobel Prize in Physiology or Medicine in 2013 for his role in revealing the machinery that regulates the transport and secretion of proteins in our cells. He shares the prize with James E. Rothman of Yale University and Thomas C. Südhof of Stanford University.
In this conversation we talk about his early career, membranes, exosomes, scientific publishing and Elife journal.
Listen to part II: https://youtu.be/MNjfkoutAhQ
Find more about Randy's work: http://mcb.berkeley.edu/labs/schekman/
Randy's biography: https://www.nobelprize.org/prizes/medicine/2013/schekman/facts/
Episode links:
Website: https://www.reasonwithscience.com/home/the-noble-journey-with-randy-schekman-i
Youtube: https://youtu.be/bl1uG4PbTOE
Spotify:
Apple podcast:
Google podcast:
Follow Reason with Science:
Website: https://www.reasonwithscience.com/
Youtube: https://www.youtube.com/channel/reasonwithscience
Spotify: https://open.spotify.com/show/5qFLGsPWjL4GAGidmF2nKh
Apple podcast: https://podcasts.apple.com/us/podcast/reason-with-science/id1641776894
Google podcast: https://podcasts.google.com/feed/aHR0cHM6Ly9hbmNob3IuZm0vcy9iMjMyNDZlOC9wb2RjYXN0L3Jzcw
Timestamps:
00:00:00 Introduction
00:01:08 Interest in microbes
00:05:27 Yeasts have feelings too!
00:06:24 What was already known about vesicular trafficking?
00:08:42 How do you envision a cell?
00:09:51 Your work to understand 'what is life'?
00:12:48 Formation of membranes for the origin of life
00:14:39 Why membranes are ideal for life!
00:15:48 Differences of membranes
00:17:07 The evolution of membranes
00:19:02 Starting the work on vesicular trafficking
00:23:09 Discovery of COPII complex
00:25:24 The specialty of COPII complex
00:26:30 Importance of vesicular trafficking for animal physiology
00:27:39 Understanding of gut feeling!
00:28:56 What has changed after Nobel prize?
00:30:30 Different cellular trafficking system
00:32:11 Exosomes and miR223
00:34:29 Problems with exosomes as therapeutics
00:35:08 Peer-review and scientific publishing
00:39:44 Genesis of Elife
00:44:05 Impact factor of Elife
00:46:35 Thank you!
More Talks from Randy:
TEDx on scientific publishing: https://youtu.be/-N4Mb8tsyT8
iBiology: https://youtu.be/xvjUgTKlKyU
Nobel prize inspiration initiative lecture: https://youtu.be/Udg6bYkBtX8
#reasonwithscience #nobelprize #cellbiology
