Margaret Keenan, who turns 91 next week, said it was the "best early birthday present".
She was given the injection at 06:31 GMT - the first of 800,000 doses of the Pfizer/BioNTech vaccine that will be dispensed in the coming weeks.
Up to four million more are expected by the end of the month.
Hubs in the UK will vaccinate over-80s and some health and care staff - the programme aims to protect the most vulnerable and return life to normal.
Health Secretary Matt Hancock, who has dubbed Tuesday V-day, said this simple act of vaccination was "a tribute to scientific endeavour and human ingenuity and to the hard work of so many people. Instagram: @cfr_news
