44th meeting between Jacksonville and Indianapolis this weekend and the final meeting of the 2022 NFL season. Unless both these rivals arrive to the tournament in January 2023. Matt Ryan and the Colts defense get another shot at Trevor Lawrence and the Jags. J'ville lost in week V while the Colts won an extremely ugly T.N.F. game against Denver. Colts lead this series 26-17 all time, all regular season games.
