🎙️ Ep. 162: Hallmarks of Aging with Lior Roitman 🎙️
Seamus and Marcos sit down with Dr. Lior Roitman, PhD in Biological Sciences and Head of Longevity Science at AI Longevity, for an illuminating conversation on the cutting-edge science of longevity and the transformative role of artificial intelligence in personalized health.
They explore how prioritizing quality of life over mere lifespan can redefine aging, the predictive power of the Birmingham Score in assessing cardiovascular risks, and the importance of understanding how individuals uniquely respond to dietary interventions like caloric restriction and fasting.
The conversation dives deep into the hallmarks of aging, with a spotlight on cellular senescence—how it contributes to health decline and how senolytics may target these aging cells to promote healthier aging.
Lior also shares how AI is revolutionizing healthcare, enabling real-time monitoring and highly personalized interventions, while also addressing the psychological and behavioral challenges of adopting sustainable health habits.
The episode wraps up with a forward-looking vision of the future of longevity research and how AI could reshape how we manage our health—for not just a longer life, but a **vibrant one**.
✨ Key Takeaways:
🧪 *Quality of life is paramount* — living well matters more than just living long
🩺 *The Birmingham Score* provides precise cardiovascular risk predictions
🧠 *Personalized medicine* starts with understanding your unique response to diet and lifestyle 🥑
⌛ *Cellular senescence* speeds up aging, but AI + senolytics offer new hope for slowing it down!
This episode is a must-listen for anyone looking to harness science and AI to unlock a healthier, longer future.
#Longevity #AgingWell #TheMacroPerspective #HealthyLiving #BioTech #AIinHealth
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Chapters
(00:00) Introduction to Longevity AI and Lior Roitman
(01:10) The Philosophy of Longevity: Quality vs. Quantity of Life
(02:34) Understanding Cardiovascular Risks and Predictive Tools
(04:09) The Birmingham Score: Predicting Health Outcomes
(06:59) Personalized Medicine: Individual Responses to Interventions
(08:03) Dietary Interventions: Caloric Restriction and Fasting
(10:46) Key Biomarkers of Aging: The Hallmarks of Aging
(14:49) Cellular Senescence: The Science Behind Aging
(20:30) Senolytics: Targeting Senescent Cells for Healthier Aging
(24:20) Aging as a Disease: New Perspectives in Research
(25:45) Psychological Aspects of Aging: Mindset and Perception
(28:31) Behavioral Change: Encouraging Healthy Habits
(32:02) Overcoming Overwhelm: The Challenge of Action
(34:05) Personalized Health Goals: The Path to Longevity
(38:42) Understanding Aging: The Hallmarks of Longevity
(43:06) AI in Health: Tailored Interventions for Individuals
(49:49) The Future of Health Monitoring: Real-Time Data and AI
(54:36) The Impact of Longevity AI: A Vision for the Future
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About Lior Roitman:
Dr. Lior Roitman is a leading Israeli molecular biologist who has made crucial contributions to our understanding of cellular senescence, chronic inflammation (often referred to as “inflammaging”), and cancer biology.
In his role as Vice President of Longevity Science at Longevity AI, Dr. Roitman leads the integration of advanced aging biology into AI-driven healthcare tools. He spearheads efforts to translate insights from senescence research—such as immune clearance pathways and SASP modulation—into personalized recommendations that improve healthspan and quality of life.
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You can find Longevity AI here:
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You can find The Macro Perspective and its hosts here:
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The Macro Perspective is hosted by Marcos Rivera and Seamus Sullivan, and was born from a simple but powerful mission: to help people take ownership of their health and lives.
