Dr. Jonathan Cedernaes (Northwestern University and Uppsala University) talks about the acute effects of sleep loss on skeletal muscle, adipose tissue and glucose metabolism. Sleep loss is associated with weight gain and loss of muscle mass in humans and insufficient sleep is considered a risk factor to develop obesity and metabolic diseases. We discuss Dr. Cedernaes' recent findings on the molecular changes in muscle and adipose tissue possibly underlying the negative metabolic impact of sleep loss.
Main paper that we discuss:
Acute sleep loss results in tissue-specific alterations in genome-wide DNA methylation state and metabolic fuel utilization in humans
https://www.science.org/doi/10.1126/sciadv.aar8590
Other papers that Jonathan refers to:
Research from Jonathan's grandfather Lennart Wetterberg
https://link.springer.com/chapter/10.1007/978-3-7091-4427-5_22
https://www.sciencedirect.com/science/article/abs/pii/0306453079900052
https://www.sciencedirect.com/science/article/abs/pii/S0079612308629623
https://pubmed.ncbi.nlm.nih.gov/?term=wetterberg+melatonin&filter=years.1970-1980&sort=date&size=100
Effects of Sleep Fragmentation on Glucose Metabolism in Normal Subjects
https://www.sciencedirect.com/science/article/pii/S0012369210600207?casa_token=q3z3AAL0Gc8AAAAA:xabjyqwSYjXm6J6eD2ba0hbVFwnfqGawDtfnzny1cxjhqDcA3jTethQcMRU8Rj7K15iNCv8s
Endogenous circadian system and circadian misalignment impact glucose tolerance via separate mechanisms in humans (Scheer's group, Morris et al. 2015)
https://www.pnas.org/content/112/17/E2225.short
Modulation of glucose regulation and insulin secretion by circadian rhythmicity and sleep (van Cauter et al. 1991)
https://www.jci.org/articles/view/115396
Sleep disturbances compared to traditional risk factors for diabetes development: Systematic review and meta-analysis (Anothaisintawee et al. 2016)
https://www.sciencedirect.com/science/article/pii/S108707921500146X?casa_token=qZDfPyRRA0AAAAAA:6Bxx4awODsQ885WNcRw3HK5Q8PevE_MbWtaRfTb9PPd-0M3T7AFH0RUMBVaxg600HKlphdOC
Acute exercise remodels promoter methylation in human skeletal muscle (Barres et al. 2012)
https://pubmed.ncbi.nlm.nih.gov/22405075/
Insufficient sleep undermines dietary efforts to reduce adiposity (Nedeltcheva et al. 2010)
https://pubmed.ncbi.nlm.nih.gov/20921542/
Correlation Patterns Between DNA Methylation and Gene Expression in The Cancer Genome Atlas (Spainhour et al. 2019)
https://journals.sagepub.com/doi/full/10.1177/1176935119828776
Effects of Posture on Gastric Emptying, Transpyloric Flow, and Hunger After a Glucose Drink in Healthy Humans (Jones et al. 2006)
https://link.springer.com/article/10.1007/s10620-005-9010-3
Right recumbent position on gastric emptying of water evidenced by 13C breath testing (Sanaka et al. 2013)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554820/
Resetting of Circadian Time in Peripheral Tissues by Glucocorticoid Signaling (Balsalobre et al. 2000)
https://www.science.org/doi/full/10.1126/science.289.5488.2344
Circadian Clock NAD+ Cycle Drives Mitochondrial Oxidative Metabolism in Mice (Peek et al. 2013)
https://www.science.org/doi/full/10.1126/science.1243417
Exercise mitigates sleep-loss-induced changes in glucose tolerance, mitochondrial function, sarcoplasmic protein synthesis, and diurnal rhythms (Saner et al. 2020)
https://www.sciencedirect.com/science/article/pii/S2212877820301848
Paradoxical sleep deprivation induces muscle atrophy (Dattilo et al. 2011)
https://onlinelibrary.wiley.com/doi/full/10.1002/mus.22322?casa_token=adEkbMYydf8AAAAA%3APgqChN4d-wpcDWvYUmzbGmNGC1hx6XfYk0OxTVzpJ_pf06x9I7pXxwBuKWoS-f43GLbtXKUTl8QRnTK7dw
Leucine supplementation is anti-atrophic during paradoxical sleep deprivation in rats (Souza et al. 2016)
https://link.springer.com/article/10.1007/s00726-015-2142-7
Circadian clock-dependent and -independent rhythmic proteomes implement distinct diurnal functions in mouse liver (Mauvoisin et al. 2014)
https://www.pnas.org/content/111/1/167.short
Effects of Sleep Fragmentation on Glucose Metabolism in Normal Subjects (Stamatakis et al. 2010) https://www.sciencedirect.com/science/article/abs/pii/S0012369210600207
Impact of Untreated Obstructive Sleep Apnea on Glucose Control in Type 2 Diabetes (Aronsohn et al. 2009)
https://www.atsjournals.org/doi/full/10.1164/rccm.200909-1423OC
Sleep Apnea and Glucose Metabolism: A Long-term Follow-up in a Community-Based Sample (Lindberg et al. 2012)
https://www.sciencedirect.com/science/article/abs/pii/S0012369212605625
Jonathan Cedernaes on Social Media:
Twitter: @JCedernaes, @SRBR_Outreach
Homepage: drcedernaes.com
at Uppsala University (Sweden): https://katalog.uu.se/profile/?id=N7-789
at Northwestern University (USA): https://northwestern.academia.edu/JonathanCedernaes
