The San Francisco 49ers’ Preseason 53-man roster prediction for 2025 is here! From Brock Purdy and Mac Jones leading the QB room to Christian McCaffrey headlining a young running back group with Isaac Guerendo and Jordan James, we break down every position battle and surprise decision.At wide receiver, Jauan Jennings and rookie Ricky Pearsall headline a deep group alongside Jacob Cowing, Jordan Watkins, Russell Gage, and Junior Bergen — with Brandon Aiyuk beginning on PUP. George Kittle anchors the tight ends, while Trent Williams and Dominick Puni lead a revamped offensive line.On defense, Nick Bosa, Bryce Huff, CJ West, and Mykel Williams headline a loaded defensive line, while Fred Warner commands a linebacker room featuring Dee Winters and Tatum Bethune. The secondary includes Deommodore Lenoir, Upton Stout, Jason Pinnock, and Ji’Ayir Brown, with special teams rounded out by Jake Moody, Thomas Morestead, and Jon Weeks.
- Surprise risers: CJ West, Upton Stout, and Russell Gage
- Tough cuts and Important Injury Updates
- Practice squad battles: Carter Bradley, Jeff Wilson Jr., Chosen Anderson, Drew Moss, and more
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