The San Francisco 49ers (3-1) head to Los Angeles for a huge Week 5 Thursday Night Football matchup against the Rams (3-1) in primetime. Coming off an ugly loss to Jacksonville that featured four turnovers, no sacks without Nick Bosa, and another special teams blunder, Kyle Shanahan’s team is desperate to bounce back.
But with Brock Purdy, Jauan Jennings, and Ricky Pearsall all questionable on a short week — and no rushing touchdowns this season — can the 49ers offense find a way to move the ball against a surging Rams defense led by Jared Verse and Aaron Donald?
Meanwhile, Matthew Stafford and Puka Nacua have been lighting up secondaries, and Kyren Williams keeps the Rams’ ground game rolling. Sean McVay’s offense is efficient, Stafford is thriving under pressure, and Los Angeles nearly entered Week 5 undefeated.
In this episode, we dive deep into:
Purdy’s injury status and the 49ers’ WR depth without Jennings & Pearsall
Why San Francisco’s pass rush must step up without Nick Bosa
How Shanahan matches up against McVay in another chapter of their rivalry
Puka Nacua vs. the 49ers’ secondary — is this a mismatch?
Special teams woes and red zone execution on both sides
Final predictions: can the 49ers steal a primetime win on the road?
It’s 49ers vs Rams on Thursday Night Football — and we’ve got your full game preview, storylines, and keys to victory right here.
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