A 62-year-old man with a history of hypertension has taken HIV PrEP with tenofovir DF/emtricitabine for 5
years.
His baseline creatinine clearance was 85 cc/min, but this has trended down with his latest creatinine
clearance 55 cc/min (repeated at 60 cc/min).
He is in a monogamous relationship with his partner who has HIV and is taking a bictegravir-based regimen
with HIV RNA <20 for years.
How would you manage his PrEP?
A. Continue tenofovir DF/emtricitabine, follow creatinine clearance monthly
B. Change to tenofovir AF/emtricitabine
C. Change to injectable cabotegravir every other month
D. Stop PrEP
