This research article investigates how plants defend themselves against bacterial pathogens beyond initial immune signaling. The authors identified erucamide, a plant-produced metabolite, as a broad-spectrum defense compound present in various plant species. They discovered that erucamide inhibits the type III secretion system (T3SS), a crucial virulence mechanism in bacteria, by directly binding to the bacterial protein HrcC, thereby disrupting its assembly. Genetic manipulation of erucamide levels in plants altered their resistance to bacterial infection, and specific mutations in HrcC rendered bacteria insensitive to erucamide's effects, highlighting this direct antivirulence mechanism as a key aspect of plant immunity.
