The sources describe a new database called The Encyclopedia of Domains (TED), which uses deep learning to identify and classify protein domains within the AlphaFold Protein Structure Database (AFDB). TED detects nearly 365 million domains, far exceeding previous methods, and reveals thousands of new folds, superfamily interactions, and domain architectures. TED expands our understanding of structural diversity across the protein universe and provides valuable insights into protein function and evolution.
Source: Exploring structural diversity across the protein universe with The Encyclopedia of Domains
ANDY M. LAU, NICOLA BORDIN , SHAUN M. KANDATHIL , IAN SILLITOE, VAISHALI P. WAMAN, JUDE WELLS, CHRISTINE A. ORENGO, AND DAVID T. JONES
SCIENCE, 1 Nov 2024, Vol 386, Issue 6721, DOI: 10.1126/science.adq4946
