We discuss a research article that. reports on a large-scale, non-randomised study evaluating the effectiveness of ring vaccination, alongside standard Ebola virus disease (EVD) control measures, during the 2018-2020 outbreak in eastern Democratic Republic of Congo. The study involved vaccinating over 265,000 individuals, primarily contacts and contacts-of-contacts of EVD cases, with the rVSV-ZEBOV-GP vaccine. Results demonstrated a significant reduction in EVD incidence ten days post-vaccination, supporting earlier findings from a randomised trial in Guinea. The study also analysed various factors influencing EVD risk and found no serious vaccine-related adverse events. Comparisons with the Guinean trial helped assess the vaccine's independent contribution to outbreak control.
