It's the worst wildlife disease disaster ever, and yet so many people haven't even heard about it.
More than 90 amphibian species extinct, hundreds more on the brink, all from a fungal disease that spread around the world before we even knew what it was.
Researchers like Dr Tiffany Kosch, from the University of Melbourne, are working hard to find an answer deep within the froggy genome, and posing some tough questions about what we might have to do to save these vital species.
Where Are We At With Frog Fungus?