The passage from Acts 13 highlights the divine initiation, practical demands, and spiritual courage required for cross-cultural missions, as the church at Antioch, marked by diverse leadership and worship, is led by the Holy Spirit to send Barnabas and Saul on a strategic mission to Cyprus and beyond. Their journey, marked by intentional travel and the inclusion of a young helper like John Mark, exemplifies the necessity of physical and cultural displacement in advancing the gospel. The confrontation with the sorcerer Elymas in Paphos underscores the reality of spiritual opposition, yet the power of God's Word—demonstrated through miraculous intervention and the conversion of the Roman proconsul—reveals that spiritual transformation is ultimately rooted in divine truth, not signs alone. The sermon emphasizes that missions flow from worship, require personal sacrifice and courage, and are not limited to foreign fields but begin with faithful witness in one's immediate sphere, with the ultimate goal of seeing God's people freed from spiritual bondage and His good works fulfilled both locally and globally. 1. Cross-Cultural Missions is Initiated by the HS 2. Cross-Cultural Missions Requires Travel 3. Cross-Cultural Missions Boldly Confronts Spiritual Strongholds