Good morning and welcome to your Thursday dose of Your Daily Meds.
Bonus Review: Which stomach cells secrete hydrogen ions? And where in the stomach are they located?
Answer: The parietal cells. They secrete H+ and Cl- into the stomach. These parietal cells are located in the fundus and body of the stomach.
Question:
Which of the following is not considered a risk factor for chorioamnionitis?
* Multiparity
* Prolonged labour
* Prolonged ruptured membranes
* Cervical insufficiency
* Alcohol usage
Have a think.
Scroll for the chat.
Query:
Which of the following clinical features is most characteristic of Type 1 Diabetes at initial presentation?
* Incidence increases with age
* Often a family history of Type 1 Diabetes
* No history of other autoimmune diseases
* Presents with polyuria and polydipsia
* Little or no weight loss
Have a think.
More scroll for more chat.
The Risk:
Chorioamnionitis is an obstetric emergency characterised by tachycardia, fever and foetal distress. It may be caused by an ascending infection that affects the membranes and amniotic fluid before affecting the foetus and is managed urgently with broad spectrum antibiotics and delivery. Chorioamnionitis is a severe, non-sexually acquired form of pelvic inflammatory disease (PID). Other forms of PID include endometritis, salpingitis, tubo-ovarian abscesses and pelvic cellulitis or peritonitis.
Important risk factors for the development of chorioamnionitis include prolonged labour and prolonged ruptured membranes. Other risk factors include cervical insufficiency, multiple digital vaginal examinations, nulliparity, meconium-stained amniotic fluid, internal foetal or uterine monitoring, alcohol and tobacco use, previous chorioamnionitis and the presence of genital tract pathogens, such as sexually transmitted infections, group B Streptococcus and bacterial vaginosis.
Multiparity is not considered a risk factor for chorioamnionitis.
Bitter Sweet:
Classifying the type of diabetes is important when determining initial management such as the need for hospitalisation or insulin commencement. Further, longer term considerations are influenced by the type of diabetes, such as risks for other autoimmune diseases (as with Type 1 Diabetes) or other metabolic conditions (as with Type 2 Diabetes).
Broadly, the typical features at initial presentation of Type 1 and Type 2 Diabetes can be classified as follows:
So an acute presentation with polyuria and polydipsia would be most characteristic of an initial presentation of Type 1 Diabetes.
Bonus: How is H+ produced in the stomach and secreted into the gastric lumen?
Answer in tomorrow’s dose.
Closing:
Thank you for taking your Meds and we will see you tomorrow for your MANE dose. As always, please contact us with any questions, concerns, tips or suggestions. Have a great day!
Luke.
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