Join us as we bypass the hype and dive straight into the biochemistry of Medium-Chain Triglycerides (MCTs). In this series, we explore how these unique fats function differently than the long-chain fats found in a standard diet, bypassing the lymphatic system to go directly to the liver for rapid oxidation and ketone production. We will examine the clinical evidence regarding MCTs and weight management, looking at studies that suggest they may increase energy expenditure and aid in the loss of subcutaneous adipose tissue compared to long-chain triglycerides.
We also tackle the controversial topic of cardiovascular health, unpacking conflicting data that shows MCTs improving cholesterol profiles in some overweight populations while potentially raising triglycerides or having neutral effects in others. Beyond the gym and the scale, we investigate the medical applications of MCTs, from their decades-long use in treating epilepsy and malabsorption disorders like short bowel syndrome to their potential role in supporting cognitive function in Alzheimer’s disease. Finally, we settle the debate between MCT oil and coconut oil, explaining why the high lauric acid content in coconut oil means it behaves more like a long-chain fat than a true metabolic hack.
Key Topics Covered:
• The Absorption Advantage: How MCTs diffuse passively into the portal system without requiring bile salts or pancreatic enzymes.
• Lipid Profile Roulette: Understanding why MCTs might lower LDL cholesterol in some contexts but increase triglycerides in others, particularly during overfeeding.
• The Coconut Confusion: Why coconut oil, which is 42% lauric acid (C12), is not a physiological equivalent to concentrated Caprylic (C8) and Capric (C10) acid supplements.
• Neurological Nuance: The science behind the ketogenic properties of MCTs and their efficacy in managing refractory epilepsy and potential cognitive decline.
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To put it simply, think of standard dietary fats (LCTs) like passengers on an international flight who must check their bags, go through long security lines, and wait at baggage claim (the lymphatic system) before finally leaving the airport. MCTs are like passengers with a diplomatic passport and only a carry-on bag; they bypass the security lines and head straight through a private exit (the portal vein) directly to their destination (the liver).Brought to you by Keppi
