#1 - Sales
A Pre-sales strategy is not available to self-published books so they can't compete with other major books because you can't talk about your book until it comes out.
#2 - Advanced Reader Copies
A self-published book is not able to get get advanced reader copies, so you're not able to get endorsements, forewards, etc. And when you are, you can only get 5 copies.
#3 - Distribution
You can't get your self-published book in stores. Most bookstores do not carry self-published books because they are not returnable.
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