Sci Guys

134: The Science of Gene Editing & Treating Blindness

Listen

Description

For the first time ever we’ve used CRISPR  to edit someone’s genes INSIDE THEIR BODY! So far we’ve been able to reverse some effects of rare genetic eye disease that results in blindness, and this is only the beginning!



You can WATCH the podcast over on our YouTube channel:

http://youtube.com/SciGuys

Help keep the show running by supporting us on Patreon!

http://patreon.com/sciguys



If you'd like to see more of us, follow our socials!



Facebook

http://facebook.com/SciGuysPod



Twitter

http://twitter.com/SciGuysPod



Instagram

http://instagram.com/SciGuysPod



Follow the SCI GUYS

@notcorry / @jampkin / @lukecutforth



References & Further Reading

  1. https://medlineplus.gov/genetics/condition/leber-congenital-amaurosis/
  2. https://rarediseases.info.nih.gov/diseases/634/leber-congenital-amaurosis
  3. https://luxturna.com

Gene Therapy
  1. https://www.nature.com/articles/d41586-018-06195-6
  2. https://www.nature.com/articles/s41587-020-0493-4
  3. https://www.nature.com/articles/s41573-019-0012-9

The EDIT-101 Trial
  1. https://clinicaltrials.gov/ct2/show/study/NCT03872479
  2. https://www.nature.com/articles/s41591-018-0327-9
  3. https://text.npr.org/2021/09/29/1040879179/vision-loss-crispr-treatment
  4. https://www.nature.com/articles/d41586-020-00655-8https://www.nature.com/articles/d41586-020-00655-8
  5. https://jamanetwork.com/journals/jama/fullarticle/2764428https://jamanetwork.com/journals/jama/fullarticle/2764428