🧬 Can we rejuvenate the aging immune system?
A new Nature Aging trial suggests we might be closer than we thought.
In 50 healthy adults aged 45–70, urolithin A—a mitophagy activator—improved immune fitness over just 28 days:
✅ ↑ naïve CD8⁺ T cells
✅ ↓ exhaustion markers (TOX)
✅ ↑ mitochondrial biogenesis (PGC-1α)
✅ ↑ fatty-acid oxidation capacity
✅ ↑ NK cell and monocyte function
✅ ↑ bacterial phagocytosis
💊 Well-tolerated with minimal adverse events
🔬 This builds on compelling translational work linking mitochondrial quality control to immunosenescence and "inflammaging."
A reminder that metabolism and immunity are deeply intertwined—and that targeted interventions may help preserve immune resilience across the lifespan.
🧠 Aging isn't just years lived. It's biology modulated.
#LongevityScience #Immunology #HealthyAging #Mitochondria #ClinicalResearch #TranslationalScience #Geroscience #ImmuneHealth #NatureAging
