In this crucial episode of "Cracking Cancer," host Dr. Kyle Concannon and patient advocate Samantha Murrell delve into Antibody Drug Conjugates (ADCs), a revolutionary class of targeted therapy. Samantha, who was treated with an ADC for her HER2 non-small cell lung cancer, shares her real-time experience with the drug's potent effects and cumulative side effects.
Dr. Concannon explains the sophisticated engineering behind ADCs: an antibody (the "key") is chemically linked to a highly toxic chemotherapy payload (the "bomb"). The goal is to specifically target cancer cells, providing the power of chemotherapy with fewer systemic side effects. The discussion covers the mechanism of action, the risks of "on-target, off-tumor" effects (hitting healthy cells with the same target), and drug "leakage" into the bloodstream, which is responsible for common side effects like nausea, fatigue, and hair loss.
This episode is a must-listen for anyone starting an ADC regimen, offering candid advice on managing side effects, the importance of open communication with your care team, and the power of patient support groups.
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The Cracking Cancer Podcast's main focus is to further education about cancer and its effects on people and communities through continued discussion and to raise funds for the continued research of cancer treatments and positive outcomes. All raised proceeds go directly to the continued upkeep of this podcast and cancer research. To find out more about supporting the show and research endeavors, please go to the following website: www.crackingcancer.org
Attributions
The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License
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