In this episode, Sabrina Paganoni, MD, PhD, Harvard Medical School, Boston, MA, James F. Howard, Jr., MD, FAAN, University of North Carolina School of Medicine, Chapel Hill, NC, and Jerry Mendell, MD, FAAN, Nationwide Children’s Hospital & Ohio State University, Columbus, OH, discuss key clinical trials in neuromuscular disorders, including the CENTAUR trials in ALS, the Phase III ADAPT trial in myasthenia gravis and the START trial long-term follow-up in SMA.