Experts discuss novel imaging biomarkers in multiple sclerosis and efforts to drive these tools into clinical practice. Jaume Sastre-Garriga, MD, PhD; Vall d'Hebron University Hospital, Barcelona; Pascal Sati, PhD, Cedars-Sinai Medical Center, Los Angeles; Letizia Leocani, MD, PhD, Scientific Institute Vita-Salute University San Raffaele, Milan; and Alberto Calvi, MD, UCL Queen Square Institute of Neurology, London, introduce their state-of-the-art research and share insights on what's to come.