In this episode of the VJNeurology podcast, we are joined by Prof. Mona Nada, MBBCh, MD, Cairo University, Cairo, Egypt, to discuss updates in the prevention, diagnosis, and treatment of cluster headache. Cluster headache is a rare but devastating primary headache disorder, often described as one of the most severe pain conditions in medicine. Characterized by recurrent attacks of severe unilateral head pain, accompanied by autonomic symptoms such as lacrimation and nasal congestion, it has a profound impact on patients’ quality of life. Despite this, cluster headache remains under-recognised and challenging to treat, making ongoing research and expert clinical insight essential.