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Did you know that a tiny molecule could have a monumental impact on your health and well-being? Nitric oxide (NO) might be the unsung hero in your body, influencing everything from blood flow and exercise performance to disease prevention and recovery.But what makes this molecule so powerful?
In this episode of the Peak Human Labs Podcast, Dr. Sanjeev Goel speaks with Dr. Nathan Bryan, a leading expert in nitric oxide physiology. They explore NO's crucial role in human health, including its impact on blood flow, circulation, and oxygen delivery. Dr. Bryan explains the two primary pathways of NO production: enzymatic synthesis from L-arginine and dietary nitrates converted by oral bacteria. They also discuss how diet, oral health, and medications like proton pump inhibitors influence NO levels. Additionally, Dr. Bryan introduces innovative NO supplementation strategies, highlighting their potential benefits for cardiovascular health and disease prevention.
Tune in to discover how this remarkable molecule could be the key to enhancing your health.
Key Takeaways
- Importance of nitric oxide (NO) in human health
- Mechanisms of nitric oxide production in the body
- Pathways of nitric oxide synthesis, including the role of nitric oxide synthase (NOS) enzymes
- Impact of diet and oral bacteria on nitric oxide levels
- Implications of nitric oxide deficiency on various health conditions
- Effects of dietary choices, particularly nitrates from vegetables, on nitric oxide production
- Relationship between endothelial function and nitric oxide
- Nitric oxide supplementation strategies and their effectiveness
- Pharmacokinetics of nitric oxide delivery methods
- Potential therapeutic applications of nitric oxide in treating diseases like ischemic heart disease and Alzheimer’s disease
In This Episode:
- [01:25] Dr. Bryan's background
- [03:13] Significance of nitric oxide
- [03:30] Misconceptions about nitric oxide
- [06:29] Mechanisms of nitric oxide production
- [08:20] Dietary influence on nitric oxide
- [09:34] Impact of oral bacteria
- [18:26] Antacids and nitric oxide deficiency
- [21:40] Young people and nitric oxide deficiency
- [22:55] Endothelial function and glycocalyx
- [24:17] Nitric oxide supplements
- [26:13] Introduction to nitric oxide
- [26:51] Mechanism of action
- [28:00] Restoring oral microbiome
- [29:01] Saliva and nitric oxide production
- [29:30] Dosage and frequency recommendations
- [31:25] Timing for optimal effects
- [32:22] Synergistic effects with medications
- [33:40] Tolerance and nitric oxide depletion
- [34:18] Details about Dr. Bryan's nitric oxide products and their benefits.
- [40:09] Conclusion and resources to learn more about nitric oxide.
Our Guest
- Dr. Nathan Bryan earned his B.S. in Biochemistry from the University of Texas at Austin and his M.D. from Louisiana State University School of Medicine, where he received the Dean’s Award for Excellence in Research. He completed post-doctoral training as a Kirschstein Fellow at Boston University's Whitaker Cardiovascular Institute. Recruited by Nobel Laureate Ferid Murad to the University of Texas Health Science Center at Houston, Dr. Bryan has pioneered nitric oxide research for 20 years, resulting in numerous patents and significant advancements in patient care. He is the Founder and CEO of Bryan Therapeutics, Inc., leading in nitric oxide-based therapies for various conditions.
Resources and Links
Peak Human Labs
Dr. Sanjeev Goel
Dr. Nathan Bryan
