The provided source details the development and evaluation of 3D-printed shellac-based devices for site-specific drug delivery to the intestine, utilizing fused deposition modeling technology. Researchers successfully fabricated shellac filaments, plasticized with polyethylene glycol (PEG 10000), that were suitable for 3D printing. The study systematically investigated how structural parameters, specifically the base and lateral wall thicknesses, influenced the device’s mechanical properties, acid resistance, and drug release kinetics. Findings confirmed that shellac offers strong gastro-protection, and that modifying the thickness allows for the precise tuning of lag time and release profiles to target different regions of the gastrointestinal tract. Ultimately, the research validates this platform as a versatile and customizable system for oral delivery of sensitive bioactive compounds.
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