In this episode, we cover everything you need to know about acetaminophen (paracetamol) toxicity — also known as Tylenol overdose. This is one of the most common drug overdoses worldwide and a leading cause of acute liver failure.
We’ll review: Safe and toxic dosing thresholds. Mechanism of action and toxic metabolic pathways (NAPQI, glutathione depletion). The four clinical stages of toxicity. Diagnostic workup and interpretation of acetaminophen levels (Rumack–Matthew nomogram). Management strategies, including NAC (N-acetylcysteine). Indications for liver transplant. Prognosis and outcomes. *Apologies for the audio, microphone didn't turn on!
Timestamps:
0:00 - 6:24 - What Is Acetaminophen, Normal Dosing, Max Doses, 2 grams/day Vs 4 grams/day.
6:25 - 7:41 - Epidemiology, Risk Factors, Liver Failure.
7:42 - 13:37 - Metabolization, Mechanism Of Toxicity, NAPQI, Glutathione
13:38 - 18:19 - 4 Stages Of Toxicity
18:20 - 26:46 - Management, Stabilization, Key Factors, Rumack Matthew Nomogram, Therapies
26:47 - 28:50 - N-Acetyl-Cysteine (NAC)
28:51 - 30:37 - Monitoring, Special Populations (Co-ingestants, Pregnancy, Etc)
30:38 - 32:14 - Liver Transplant, King's College Criteria, Prognosis
32:15 - 38:51 - Key Points, Review, Practice Questions
Link to YouTube Video:
https://www.youtube.com/watch?v=hlXF8GwrT98
📚 Related Resources:
Download our Tylenol Overdose study guides and practice questions: https://www.patreon.com/collection/1443765
Watch next: Playlist Critical Care Medicine
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