In this high-yield medical education podcast, we explore hydroxocobalamin — a lesser-known but powerful adjunct vasopressor used in vasoplegic shock and cyanide toxicity. Learn how this vitamin B12 analog exerts potent effects on vascular tone and when to use it in the ICU.
📌 What you’ll learn in this podcast: What is hydroxocobalamin? Mechanism of action: nitric oxide scavenger, catecholamine-sparing effects Clinical uses in vasoplegic shock, cyanide poisoning, and refractory hypotension Receptor-independent vasoconstriction explained simply Dosing strategies and administration pearls Side effects: red discoloration, lab interference, hypertension Key clinical evidence and use in cardiac surgery or critical care Summary + board-style practice questions 🎯 Ideal for learners preparing for USMLE Step 2/3, critical care boards, or managing shock and toxicologic emergencies in the ICU or ED.
📚 Related Resources: Download our hydroxocobalamin study guide and practice questions: https://www.patreon.com/collection/1443765
Watch next: Playlist Vasopressors and Inotropes: https://youtube.com/playlist?list=PLf5bMa9_tvRg_nAnm91hsyHhI0y_ahoS1&si=Myz25vHJgHAp4Nvc
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