That God created man male and female is the most important foundational thing to the divine order of Creation. This fact is repeated in the story of Creation and in the New Testament by Jesus himself. In order to destroy man Satan always begins by breaking down this pillar of the divine order and thereby destroying the image of God in which man was created. Both male and female have their strengths and weaknesses, and they have their roles in life precisely laid out in the Word of God. When confusion and disorder is introduced to the distinction and roles of men and women it leads to complete abandonment of God and a return to paganism. This is the spirit of Jezebel we read about in Revelation 2:20.
