This paper describes The Spatial Atlas of Human Anatomy (SAHA), an innovative and comprehensive resource that maps human tissues at subcellular resolution. SAHA integrates spatial transcriptomics, proteomics, and histological data from over 100 healthy donors, primarily focusing on gastrointestinal and immune systems. This atlas provides a healthy tissue reference that allows for comparative analysis with diseased tissues, such as colorectal cancer and inflammatory bowel disease, revealing disease-associated spatial disruptions and offering insights into therapeutic responses. The data is openly accessible through a FAIR-compliant portal, establishing a foundational framework for spatial diagnostics and precision medicine.
References:
