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This article from Nature Medicine explores resilience as a key factor in brain health across diverse global populations, particularly emphasizing the majority world. It examines resilience through biological, psychological, social, and environmental lenses, highlighting how factors like genetics, exposome, allostatic interoception, nutrition, sex, gender, ethnicity, and age influence an individual's ability to adapt to adversity. The text stresses the urgent need for culturally sensitive measurement tools and interventions that address systemic inequities and promote sustainable, community-driven strategies to enhance brain health globally. The authors advocate for an integrated, multi-level approach that moves beyond traditional, individualistic perspectives to account for broader societal and environmental influences on resilience.

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