At the end of the 15th Century the Age of Discovery and Exploration was just beginning. In 1534 Jacques Cartier made contact with the Iroquoian peoples of the St. Lawrence River valley. It was all downhill from there. In fact things will never be the same. Old World pathogens will soon destroy anyone's way of life who happens to call the Americas home.
Sources-
Iroquoia: The Development of a Native World: Iroquois & Their Neighbors by William Engelbrecht and Caleb Rector
THE JESUITS IN NORTH AMERICA IN THE SEVENTEENTH CENTURY BY FRANCIS PARKMEN
IROQUOIS DIPLOMACY ON THE EARLY AMERICAN FRONTIER BY TIMOTHY J. SHANNON
1491: NEW REVELATIONS OF THE AMERICAS BEFORE COLUMBUS BY CHARLES MANN
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